BMP-11/GDF-11, human recombinant | 7155

GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. Recombinant human GDF-11 is a 25.0 kDa disulfide-linked homodimer containing two 109 amino acid polypeptide chains. It is highly homologous to myostatin/GDF-8 sharing 90% amino acid sequence identity.

7155 | BMP-11/GDF-11 human recombinant DataSheet

Biomolecule/Target: BMP-11

Synonyms: Growth/Differentiation Factor-11, BMP-11

Alternates names: Fatty acid-binding protein 5, Fatty acid-binding protein epidermal, Epidermal-type fatty acid-binding protein, E-FABP, Fatty acid-binding protein 5, Psoriasis-associated fatty acid-binding protein homolog, PA-FABP

Taglines: Suppresses neurogenesis through a myostatin-like pathway

NCBI Gene ID #: 2171

NCBI Gene Symbol: FABP5

Gene Source: Human

Accession #: Q01469

Recombinant: Yes

Source: E. coli.

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: < 0.1 ng/g of protein (<1EU/g).

Activity (Specifications/test method): Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 0.08-0.10 g/ml.

Biological activity: Test in process

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 16 kDa

Concentration: N/A

Appearance: Lyophilized powder

Physical form description: Sterile filtered through a 0.2 micron filter. Lyophilized with no additives.

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers

Amino acid sequence: N/A