BMS-3 | B2298

BMS-3 is a potent and specific inhibitor of activated LIM domain kinases LIMK1 and LIMK2 (IC₅₀s = 5 and 6 nM, respectively). LIMK1 is responsible for the inactivation of cofilin (ADF family protein), leading to actin reorganization. It is upregulated in several invasive cancers.

BMS-3 is a potent and specific inhibitor of activated LIM domain kinases LIMK1 and LIMK2 (IC₅₀s = 5 and 6 nM, respectively). LIMK1 is responsible for the inactivation of cofilin (ADF family protein), leading to actin reorganization. It is upregulated in several invasive cancers.

B2298 | BMS-3 DataSheet

Alternate Name/Synonyms: N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-cyclopropanecarboxamide

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1338247-30-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₂Cl₂F₂N₄OS

Molecular Weight: 429.27

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO (~10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and specific inhibitor of activated LIM domain kinases (LIMK1 and LIMK2)

MDL Number: N/A

PubChem CID: 73265272

SMILES: C1CC1C(=O)NC2=NC=C(S2)C3=CC(=NN3C4=C(C=CC=C4Cl)Cl)C(F)F

InChi: InChI=1S/C17H12Cl2F2N4OS/c18-9-2-1-3-10(19)14(9)25-12(6-11(24-25)15(20)21)13-7-22-17(27-13)23-16(26)8-4-5-8/h1-3,6-8,15H,4-5H2,(H,22,23,26)

InChi Key: YBGGBHCJSAEIAS-UHFFFAOYSA-N