Description
BMS-303141 is a potent inhibitor of ATP citrate lyase (ACL) (IC₅₀ = 0.13 µM for human recombinant ACL). BMS-303141 inhibits lipid synthesis in HepG2 cells with an IC₅₀ of 8 μM, and lowers plasma triglycerides in a murine hyperlipdemia model
BMS-303141 is a potent inhibitor of ATP citrate lyase (ACL) (IC₅₀ = 0.13 µM for human recombinant ACL). BMS-303141 inhibits lipid synthesis in HepG2 cells with an IC₅₀ of 8 μM, and lowers plasma triglycerides in a murine hyperlipdemia model
Alternate Name/Synonyms: 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide
Appearance: White solid
Formulation: N/A
CAS Number: 943962-47-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₁₅Cl₂NO₄S
Molecular Weight: 424.3
Cell-Permeable?: yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~10 mg/ml) or EtOH (~ 20 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent inhibitor of ATP citrate lyase (ACL)
MDL Number: N/A
PubChem CID: 16747776
SMILES: COC1=C(C=C(C=C1)C2=CC=CC=C2)NS(=O)(=O)C3=CC(=CC(=C3O)Cl)Cl
InChi: InChI=1S/C19H15Cl2NO4S/c1-26-17-8-7-13(12-5-3-2-4-6-12)9-16(17)22-27(24,25)18-11-14(20)10-15(21)19(18)23/h2-11,22-23H,1H3
InChi Key: SIIPNDKXZOTLEA-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |