BMS-345541 (Free base) | B1907

BMS-345541 is a highly selective inhibitor of IKK-1 and IKK-2 with IC₅₀ value of 4 μM and 0.3 μM, respectively. It binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. Cell-permeable.

BMS-345541 is a highly selective inhibitor of IKK-1 and IKK-2 with IC₅₀ value of 4 μM and 0.3 μM, respectively. It binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. Cell-permeable.

B1907 | BMS-345541 (Free base) DataSheet

Alternate Name/Synonyms: N-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 445430-58-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₄H₁₇N₅

Molecular Weight: 255.32

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A highly selective inhibitor of IKK-1 and IKK-2

MDL Number: MFCD07784499

PubChem CID: 9813758

SMILES: CC1=CC2=C(C=C1)N=C(C3=NC=C(N23)C)NCCN

InChi: InChI=1S/C14H17N5/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18)

InChi Key: PSPFQEBFYXJZEV-UHFFFAOYSA-N