BMS-863233 hydrochloride | 2598

BMS-863233 is a potent and selective CDC7 (cell division cycle 7 homolog) inhibitor. BMS-863233 binds to and inhibits the activity of CDC7, resulting in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. CDC7, a serine-threonine kinase overexpressed in a variety of tumor cell types, plays an essential role in the initiation of DNA replication by activating origins of replication.

BMS-863233 is a potent and selective CDC7 (cell division cycle 7 homolog) inhibitor. BMS-863233 binds to and inhibits the activity of CDC7, resulting in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. CDC7, a serine-threonine kinase overexpressed in a variety of tumor cell types, plays an essential role in the initiation of DNA replication by activating origins of replication.

2598 | BMS-863233 hydrochloride DataSheet

Alternate Name/Synonyms: (S)-8-chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride; XL-413 hydrochloride

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1169562-71-3

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₄H₁₃Cl₂N₃O₂

Molecular Weight: 326.17

Cell-Permeable?: Yes

Purity: >98% by HPLC

Solubilities: DMSO

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent and selective CDC7 inhibitor

MDL Number: N/A

PubChem CID: 57899889

SMILES: C1CC(NC1)C2=NC(=O)C3=C(N2)C4=C(O3)C=CC(=C4)Cl

InChi: InChI=1S/C14H12ClN3O2/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9/h3-4,6,9,16H,1-2,5H2,(H,17,18,19)/t9-/m0/s1

InChi Key: JJWLXRKVUJDJKG-VIFPVBQESA-N