BMS-911543 | 2630

BMS-911543 is a potent and selective JAK2 inhib itor. It displays potent anti-proliferative and pharmacodynamic effects in cell lines dependent upon JAK2 signaling, and has little activity in cell types dependent upon other pathways, such as JAK1 and JAK3. In addition, it displays anti-proliferative responses in colony growth assays using primary progenitor cells isolated from patients with JAK2(V617F)-positive myeloproliferative neoplasms (MPNs).

BMS-911543 is a potent and selective JAK2 inhib itor. It displays potent anti-proliferative and pharmacodynamic effects in cell lines dependent upon JAK2 signaling, and has little activity in cell types dependent upon other pathways, such as JAK1 and JAK3. In addition, it displays anti-proliferative responses in colony growth assays using primary progenitor cells isolated from patients with JAK2(V617F)-positive myeloproliferative neoplasms (MPNs).

2630 | BMS-911543 DataSheet

Alternate Name/Synonyms: N,N-dicyclopropyl-4-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide ; BMS911543

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1271022-90-2

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₈N₈O

Molecular Weight: 432.52

Cell-Permeable?: Yes

Purity: >98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective JAK2 inhibitor

MDL Number: N/A

PubChem CID: 50922691

SMILES: CCN1C(=CC2=C3C(=C(N=C21)NC4=NN(C(=C4)C)C)N=CN3C)C(=O)N(C5CC5)C6CC6

InChi: nChI=1S/C23H28N8O/c1-5-30-17(23(32)31(14-6-7-14)15-8-9-15)11-16-20-19(24-12-28(20)3)21(26-22(16)30)25-18-10-13(2)29(4)27-18/h10-12,14-15H,5-9H2,1-4H3,(H,25,26,27)

InChi Key: JCINBYQJBYJGDM-UHFFFAOYSA-N