BMS-935177 | B2791

BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor (IC50 = 2.8 nM). It is more potent against BTK than other kinases, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective.

BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor (IC50 = 2.8 nM). It is more potent against BTK than other kinases, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective.

B2791 | BMS-935177 DataSheet

Alternate Name/Synonyms: 7-(2-hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxoquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide

Appearance: Crystalline solid

Formulation:

CAS Number: 1231889-53-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₁H₂₆N₄O₃

Molecular Weight: 502.56

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >100 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent BTK (Bruton's Tyrosine Kinase) inhibitor

MDL Number:

PubChem CID: 70647728

SMILES: CC1=C(C=CC=C1N2C=NC3=CC=CC=C3C2=O)C4=C5C6=C(C=C(C=C6)C(C)(C)O)NC5=C(C=C4)C(=O)N

InChi: InChI=1S/C31H26N4O3/c1-17-19(8-6-10-26(17)35-16-33-24-9-5-4-7-22(24)30(35)37)20-13-14-23(29(32)36)28-27(20)21-12-11-18(31(2,3)38)15-25(21)34-28/h4-16,34,38H,1-3H3,(H2,32,36)

InChi Key: TVJRDCQUZMGBAB-UHFFFAOYSA-N