Description
BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor (IC50 = 2.8 nM). It is more potent against BTK than other kinases, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective.
BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor (IC50 = 2.8 nM). It is more potent against BTK than other kinases, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective.
Alternate Name/Synonyms: 7-(2-hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxoquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide
Appearance: Crystalline solid
Formulation:
CAS Number: 1231889-53-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₃₁H₂₆N₄O₃
Molecular Weight: 502.56
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: >100 mg/ml DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A potent BTK (Bruton's Tyrosine Kinase) inhibitor
MDL Number:
PubChem CID: 70647728
SMILES: CC1=C(C=CC=C1N2C=NC3=CC=CC=C3C2=O)C4=C5C6=C(C=C(C=C6)C(C)(C)O)NC5=C(C=C4)C(=O)N
InChi: InChI=1S/C31H26N4O3/c1-17-19(8-6-10-26(17)35-16-33-24-9-5-4-7-22(24)30(35)37)20-13-14-23(29(32)36)28-27(20)21-12-11-18(31(2,3)38)15-25(21)34-28/h4-16,34,38H,1-3H3,(H2,32,36)
InChi Key: TVJRDCQUZMGBAB-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
60 months |