Description
BMS-986158 is a potent bromodomain (BRD) and extra-terminal domain (BET) family inhibitor. BMS-986158 binds to the acetyl-lysine binding site in the BRD of BET proteins, thereby preventing the interaction between BET proteins and acetylated histones. This disrupts chromatin remodeling and prevents the expression of certain growth-promoting genes, resulting in an inhibition of tumor cell growth.
BMS-986158 is a potent bromodomain (BRD) and extra-terminal domain (BET) family inhibitor. BMS-986158 binds to the acetyl-lysine binding site in the BRD of BET proteins, thereby preventing the interaction between BET proteins and acetylated histones.
Alternate Name/Synonyms: (S)-2-(3-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-5-(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-5H-pyrido[3,2-b]indol-7-yl)propan-2-ol
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1800340-40-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₃₀H₃₃N₅O₂
Molecular Weight: 495.63
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent bromodomain (BRD) and extra-terminal domain (BET) family inhibitor
MDL Number: N/A
PubChem CID: 118196485
SMILES: CC1=C(N(N=N1)C)C2=CC3=C(C4=C(N3C(C5CCOCC5)C6=CC=CC=C6)C=C(C=C4)C(C)(C)O)N=C2
InChi: InChI=1S/C30H33N5O2/c1-19-28(34(4)33-32-19)22-16-26-27(31-18-22)24-11-10-23(30(2,3)36)17-25(24)35(26)29(20-8-6-5-7-9-20)21-12-14-37-15-13-21/h5-11,16-18,21,29,36H,12-15H2,1-4H3/t29-/m1/s1
InChi Key: KGERZPVQIRYWRK-GDLZYMKVSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |
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