BMS-P5 | B3135

BMS-P5 is a potent and selective inhibitor of peptidylarginine deiminase 4 (PAD4). It significantly reduces Multiple myeloma-cells induced citrullination of histone H3 and formation of neutrophil extracellular trap at a concentration of 1 μM. It delays appearance of symptoms and disease progression in Multiple myeloma bearing mice.

BMS-P5 is a potent and selective inhibitor of peptidylarginine deiminase 4 (PAD4). It significantly reduces Multiple myeloma-cells induced citrullination of histone H3 and formation of neutrophil extracellular trap at a concentration of 1 μM. It delays appearance of symptoms and disease progression in Multiple myeloma bearing mice.

B3135 | BMS-P5 DataSheet

Alternate Name/Synonyms: [(2S,5R)-5-amino-2-methylpiperidin-1-yl]-[2-[1-(cyclopropylmethyl)pyrrolo[2,3-b]pyridin-2-yl]-7-methoxy-1-methylbenzimidazol-5-yl]methanone; EX-A4667

Appearance: White solid

Formulation:

CAS Number: 1550371-22-6

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₂₇H₃₂N₆O₂

Molecular Weight: 472.6

Cell-Permeable?: TRUE

Purity: ≥ 97%

Solubilities: ~30 mg/ml in ethanol ~5 mg/ml in DMSO ~20 mg/ml in DMF or Dichloromethane

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective inhibitor of PAD4

MDL Number:

PubChem CID: 118158953

SMILES: CC1CCC(CN1C(=O)C2=CC3=C(C(=C2)OC)N(C(=N3)C4=CC5=C(N4CC6CC6)N=CC=C5)C)N

InChi: InChI=1S/C27H32N6O2/c1-16-6-9-20(28)15-32(16)27(34)19-11-21-24(23(13-19)35-3)31(2)26(30-21)22-12-18-5-4-10-29-25(18)33(22)14-17-7-8-17/h4-5,10-13,16-17,20H,6-9,14-15,28H2,1-3H3/t16-,20+/m0/s1

InChi Key: PXJXCBYHGJEEJH-OXJNMPFZSA-N