Description
BPTES is an allosteric glutaminase (GLS1) inhibitor (IC₅₀ = 3.3 μM). Displays selectivity for GLS1 over GLS2 and γ-glutamyl transpeptidase. Induces cell death of P493 human lymphoma B cells in vitro and reduces tumor volume of P493 cell xenografts in mice.
BPTES is an allosteric glutaminase (GLS1) inhibitor (IC₅₀ = 3.3 μM). Displays selectivity for GLS1 over GLS2 and γ-glutamyl transpeptidase. Induces cell death of P493 human lymphoma B cells in vitro and reduces tumor volume of P493 cell xenografts in mice.
Alternate Name/Synonyms: N,N'-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide
Appearance: White solid
Formulation: N/A
CAS Number: 314045-39-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₄H₂₄N₆O₂S₃
Molecular Weight: 524.68
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~10 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An allosteric glutaminase (GLS1) inhibitor
MDL Number: MFCD01079848
PubChem CID: 3372016
SMILES: C1=CC=C(C=C1)CC(=O)NC2=NN=C(S2)CCSCCC3=NN=C(S3)NC(=O)CC4=CC=CC=C4
InChi: InChI=1S/C24H24N6O2S3/c31-19(15-17-7-3-1-4-8-17)25-23-29-27-21(34-23)11-
InChi Key: MDJIPXYRSZHCFS-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |