BPTES | B2165

BPTES is an allosteric glutaminase (GLS1) inhibitor (IC₅₀ = 3.3 μM). Displays selectivity for GLS1 over GLS2 and γ-glutamyl transpeptidase. Induces cell death of P493 human lymphoma B cells in vitro and reduces tumor volume of P493 cell xenografts in mice.

BPTES is an allosteric glutaminase (GLS1) inhibitor (IC₅₀ = 3.3 μM). Displays selectivity for GLS1 over GLS2 and γ-glutamyl transpeptidase. Induces cell death of P493 human lymphoma B cells in vitro and reduces tumor volume of P493 cell xenografts in mice.

B2165 | BPTES DataSheet

Alternate Name/Synonyms: N,N'-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide

Appearance: White solid

Formulation: N/A

CAS Number: 314045-39-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₄N₆O₂S₃

Molecular Weight: 524.68

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An allosteric glutaminase (GLS1) inhibitor

MDL Number: MFCD01079848

PubChem CID: 3372016

SMILES: C1=CC=C(C=C1)CC(=O)NC2=NN=C(S2)CCSCCC3=NN=C(S3)NC(=O)CC4=CC=CC=C4

InChi: InChI=1S/C24H24N6O2S3/c31-19(15-17-7-3-1-4-8-17)25-23-29-27-21(34-23)11-

InChi Key: MDJIPXYRSZHCFS-UHFFFAOYSA-N