BQ-123 Sodium Salt | B1552

BQ-123 sodium is a potent and selective ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively). It also inhibits ET-1 receptor binding and blocks Ca²⁺ mobilization, cellular contraction and MAP kinase activation.

BQ-123 sodium is a potent and selective ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively). It also inhibits ET-1 receptor binding and blocks Ca²⁺ mobilization, cellular contraction and MAP kinase activation.

B1552 | BQ-123 Sodium Salt DataSheet

Alternate Name/Synonyms: Cyclo (D-Trp-D-Asp-Pro-D-Val-Leu) ; Endothelin Receptor A Antagonist BQ-123

Appearance: White lyophilized solid

Formulation: N/A

CAS Number: 136553-81-6 (Free acid)

Structure Available?: Yes

Peptide sequence: Cyclo (D-Trp-D-Asp-Pro-D-Val-Leu)

Salt Form: N/A

Molecular Formula: C₃₁H₄₂N₆O₇•Na

Molecular Weight: 633.69

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: H₂O

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent and selective ETA endothelin receptor antagonist

MDL Number: MFCD00133204

PubChem CID: 443289

SMILES: CC(C)CC1C(=O)NC(C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)C(C)C)CC(=O)O)CC3=CNC4=CC=CC=C43

InChi: InChI=1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,23+,24-,26+/m0/s1

InChi Key: VYCMAAOURFJIHD-PJNXIOHISA-N