Description
BQ-788 is a potent and selective antagonist of endothelin (ET) B-receptor (IC₅₀ = 1.2 nM). BQ-788 is a good tool for demonstrating the role of ET-1 and ET(B) receptor subtypes in physiological and/or pathophysiological conditions. Q-788 competitively antagonizes the vasoconstriction induced by an ETB-selective agonist on isolated rabbit pulmonary arteries, blocks ET-1 induced bronchoconstriction in guinea pigs, and abolishes an ET-1 mediated depressor response in rats.
BQ-788 is a potent and selective antagonist of endothelin (ET) B-receptor (IC₅₀ = 1.2 nM). BQ-788 is a good tool for demonstrating the role of ET-1 and ET(B) receptor subtypes in physiological and/or pathophysiological conditions. Q-788 competitively antagonizes the vasoconstriction induced by an ETB-selective agonist on isolated rabbit pulmonary arteries, blocks ET-1 induced bronchoconstriction in guinea pigs, and abolishes an ET-1 mediated depressor response in rats.
B1554 | BQ-788 Sodium Salt DataSheet
Alternate Name/Synonyms: (2R)-2-[[(2R)-2-amino-3-(1-methoxycarbonylindol-3-yl)propanoyl]-[(2S)-2-[[(2R,6S)-2,6-dimethylpiperidine-1-carbonyl]amino]-4,4-dimethylpentanoyl]amino]hexanoate, sodium
Appearance: White lyophilized solid
Formulation: N/A
CAS Number: 156161-89-6
Structure Available?: Yes
Peptide sequence: 1. N-2,6-dimethylpiperidinocarbonyl-gamma-MeLeu-Trp(COOMe)-Nle-ONa
Salt Form: N/A
Molecular Formula: C₃₄H₅₀N₅O₇Na
Molecular Weight: 663.79
Cell-Permeable?: Yes
Purity: ≥97% by HPLC
Solubilities: DMSO (~ 5 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: a potent and selective antagonist of endothelin (ET) B-receptor
MDL Number: MFCD00797882
PubChem CID: 16759603
SMILES: CCCCC(C(=O)[O-])NC(=O)C(CC1=CN(C2=CC=CC=C21)C(=O)OC)NC(=O)C(CC(C)(C)C)NC(=O)N3C(CCCC3C)C.[Na+]
InChi: InChI=1S/C34H51N5O7.Na/c1-8-9-16-25(31(42)43)35-29(40)26(18-23-20-38(33(45)46-7)28-17-11-10-15-24(23)28)36-30(41)27(19-34(4,5)6)37-32(44)39-21(2)13-12-14-22(39)3;/h10-11,15,17,20-22,25-27H,8-9,12-14,16,18-19H2,1-7H3,(H,35,40)(H,36,41)(H,37,44)(H,42,43);/q;+1/p-1/t21-,22+,25-,26-,27+;/m1./s1
InChi Key: QCVIFBRTTLMEOV-FUKQNADPSA-M
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |