Bromosporine | 2652

Bromosporine is a broad spectrum bromodomain inhibitor (IC₅₀s = 0.41 µM, 0.29 µM, 0.122 µM and 0.017 µM for BRD2, BRD4, BRD9 and CECR2, respectively). At 1 µM, Bromosporine accelerates FRAP recovery of BRD4 and CREBBP, while displaying no activities against TIF1α, BAZ2A, and SMARCA2 even at 10 µM.

Bromosporine is a broad spectrum bromodomain inhibitor (IC₅₀s = 0.41 µM, 0.29 µM, 0.122 µM and 0.017 µM for BRD2, BRD4, BRD9 and CECR2, respectively). At 1 µM, Bromosporine accelerates FRAP recovery of BRD4 and CREBBP, while displaying no activities against TIF1α, BAZ2A, and SMARCA2 even at 10 µM.

2652 | Bromosporine DataSheet

Alternate Name/Synonyms: Ethyl (3-methyl-6-(4-methyl-3-(methylsulfonamido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate

Appearance: White solid

Formulation: N/A

CAS Number: 1619994-69-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₂₀N₆O₄S

Molecular Weight: 404.44

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~35 mg/ml) or EtOH (~ 10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A bromodomain family inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C(OCC)NC1=CC(C2=CC=C(C)C(NS(=O)(C)=O)=C2)=NN3C1=NN=C3C

InChi: InChI=1S/C17H20N6O4S/c1-5-27-17(24)18-15-9-14(21-23-11(3)19-20-16(15)23)12-7-6-10(2)13(8-12)22-28(4,25)26/h6-9,22H,5H2,1-4H3,(H,18,24)

InChi Key: UYBRROMMFMPJAN-UHFFFAOYSA-N