Description
BS-181 dihydrochloride is a potent and selective CDK7 inhibitor (IC₅₀ = 21 nM). It displays >40-fold selectivity for CDK7 over others CDKs. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice.
BS-181 dihydrochloride is a potent and selective CDK7 inhibitor (IC₅₀ = 21 nM). It displays >40-fold selectivity for CDK7 over others CDKs. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice.
B2180 | BS-181 dihydrochloride DataSheet
Alternate Name/Synonyms: N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride
Appearance: White solid
Formulation: N/A
CAS Number: 1092443-52-1 (free base)
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₃₂N₆.2HCl
Molecular Weight: 453.45
Cell-Permeable?: Yes
Purity: ≥97% by HPLC
Solubilities: DMSO (>40 mg/ml) or H2O (>40 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A potent and selective CDK7 inhibitor
MDL Number: N/A
PubChem CID: 49867928
SMILES: CC(C)C1=C2N=C(C=C(N2N=C1)NCC3=CC=CC=C3)NCCCCCCN.Cl
InChi: InChI=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22(19)28)24-13-9-4-3-8-12-23;/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2,1-2H3,(H,24,27);1H
InChi Key: NVIJWMOQODWNFN-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |