BS-181 dihydrochloride | B2180

BS-181 dihydrochloride is a potent and selective CDK7 inhibitor (IC₅₀ = 21 nM). It displays >40-fold selectivity for CDK7 over others CDKs. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice.

BS-181 dihydrochloride is a potent and selective CDK7 inhibitor (IC₅₀ = 21 nM). It displays >40-fold selectivity for CDK7 over others CDKs. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice.

B2180 | BS-181 dihydrochloride DataSheet

Alternate Name/Synonyms: N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride

Appearance: White solid

Formulation: N/A

CAS Number: 1092443-52-1 (free base)

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₃₂N₆.2HCl

Molecular Weight: 453.45

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO (>40 mg/ml) or H2O (>40 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent and selective CDK7 inhibitor

MDL Number: N/A

PubChem CID: 49867928

SMILES: CC(C)C1=C2N=C(C=C(N2N=C1)NCC3=CC=CC=C3)NCCCCCCN.Cl

InChi: InChI=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22(19)28)24-13-9-4-3-8-12-23;/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2,1-2H3,(H,24,27);1H

InChi Key: NVIJWMOQODWNFN-UHFFFAOYSA-N