BSJ-03-123 | B2747

BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC). BSJ-03-123 causes a pronounced anti-proliferative effect in CDK6-dependent AML cell lines by inducing a G1 cell-cycle arrest without a measurable increase in apoptosis.

BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC). BSJ-03-123 causes a pronounced anti-proliferative effect in CDK6-dependent AML cell lines by inducing a G1 cell-cycle arrest without a measurable increase in apoptosis.

B2747 | BSJ-03-123 DataSheet

Alternate Name/Synonyms: BSJ-03123,N-(2-(2-(2-(2-(4-(6-((3-acetyl-1-cyclopentyl-4-methyl-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide

Appearance: Yellow solid

Formulation:

CAS Number: 2361493-16-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₄₇H₅₆N₁₀O₁₁

Molecular Weight: 937.02

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >60 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: CDK6-selective small-molecule degrader

MDL Number:

PubChem CID: 137628658

SMILES: O=C1N(C2=NC(NC3=CC=C(C=N3)N4CCN(CCOCCOCCOCCNC(COC5=C(C(N(C6C(NC(CC6)=O)=O)C7=O)=O)C7=CC=C5)=O)CC4)=NC=C2C(C)=C1C(C)=O)C8CCCC8

InChi: InChI=1S/C47H56N10O11/c1-29-34-27-50-47(53-42(34)56(31-6-3-4-7-31)45(63)40(29)30(2)58)51-37-12-10-32(26-49-37)55-17-15-54(16-18-55)19-21-66-23-25-67-24-22-65-20-14-48-39(60)28-68-36-9-5-8-33-41(36)46(64)57(44(33)62)35-11-13-38(59)52-43(35)61/h5,8-10,12,26-27,31,35H,3-4,6-7,11,13-25,28H2,1-2H3,(H,48,60)(H,52,59,61)(H,49,50,51,53)

InChi Key: LUHCYAOYQIFNRN-UHFFFAOYSA-N