BTLA Antibody | 7473

BTLA Antibody | 7473 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: N/A

Immunogen: BTLA antibody was raised against a 17 amino acid peptide near the center of human BTLA.
The immunogen is located within amino acids 170 - 220 of BTLA .

Research Area: Innate Immunity

Tested Application: E, WB, IHC-P, IF

Application: BTLA antibody can be used for detection of BTLA by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: BTLA antibody is human specific. At least two isoforms of BTLA are known to exist.

Positive Control 1: Cat. No. 1205 - Jurkat Cell Lysate

Positive Control 2: Cat. No. 11-801 - Human Small Intestine Tissue Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 32 kDa
Observed: 40kDa

Validation: N/A

Isoform: N/A

Purification: BTLA Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: BTLA Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: BTLA antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: BTLA Antibody : BTLA1, CD272, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The B- and T-lymphocyte attenuator (BTLA) protein is a member of the immunoglobulin superfamily containing a single immunoglobulin (Ig) domain (1) . Like other coihibitory receptors such as CTLA-4 and PD-1, BTLA functions as a receptor that relays inhibitory signals to suppress the immune response, and can inhibit LPS-induced endotoxic shock by suppressing TLR4 signaling in innate immune cells (1, 2) . Polymorphisms in this gene have also been associated with an increased risk of rheumatoid arthritis (3) .