BubR1 polyclonal Antibody | BS90152

BubR1 polyclonal Antibody | BS90152 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB ICC IHC FC

Application Range: WB:1:5,000-1:10,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: Human cells contain two related protein kinases, BUB1 and BUBR1, that appear to have evolved from a single ancestral BUB1 gene. Both kinases are concentrated near the surface of the kinetochore where they monitor kinetochore-microtubule interactions. BUB1 and BUBR1 bind to kinetochores and are postulated to be components of the mitotic checkpoint, which monitors kinetochore activities to determine if chromosomes have achieved alignment at the spindle equator. BUBR1 is essential for normal mitotic progression as it prevents cells from prematurely entering anaphase. BUB3 is a conserved component of the mitotic spindle assembly complex and is also involved with the essential spindle checkpoint pathway that operates during early embryogenesis.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: BubR1 polyclonal Antibody detects endogenous levels of BubR1 protein.

Molecular Weight: 119 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: hBUBR1, BUB1B, BUBR1, MAD3L, SSK1, Beta homolg of S. cerevisiae BUB 1, Beta homolg of S. cerevisiae budding uninhibited by benzimidazoles, BUB 1B, BUB1 budding uninhibited by benzimidazoles 1 homolog beta, Bub1A, BUB1B, BUB1B, BUB1beta, BUBR1, Budding Uninhibited by Benzimidazoles 1 beta, Budding uninhibited by benzimidazoles 1 homolog beta (yeast), hBUBR1, MAD3/BUB1 related protein kinase, MAD3/BUB1-related protein kinase, MAD3L, Mitotic checkpoint gene BUB1B, Mitotic checkpoint kinase MAD3L, Mitotic checkpoint serine/threonine protein kinase BUB1 beta, Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, MVA1, OTTHUMP00000160319, Protein SSK1, SSK 1, SSK1,

Immunogen: Recombinant protein within human BubR1 330-600 aa.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein affinity purified.

Pathway: