26
BugDisc™ Nitrocefin Disc | M1251
- SKU:
- 26-M1251-GEN
- Availability:
- Usually shipped in 5 working days
Description
Beta-Lactamases (βLs), are hydrolases expressed in Gram-positive and Gram-negative bacteria. When those bacteria encounter β-lactam antibiotics which contain the four atom ring-structure, they secrete βLs and hydrolyze these compounds. Antibiotics containing β-lactam rings (i.e. penicillin, cephalosporin, monobactam, carbapenem) are highly susceptible to be hydrolyzed via enzymatic activity, which deactivates their antibiotic potency. βLs are a significant clinical threat because of the bacterial strains with β-lactam antibiotic resistance. Resistance in gram-negative organisms may be caused by chromosomally or plasmid-mediated β-lactamases, and there is an increase in antibiotic resistance in bacteria in both community infections or hospital acquired infections. ’s Nitrocefin Discs offer a simple and sensitive assay that can detect the presence of β-lactamase enzymatic activity. The qualitative detection test is based on the hydrolysis of Nitrocefin, a yellow-colored β-Lactamase substrate impregnated into a filter paper disc. Upon incubation with β-lactamase producing bacteria and cleavage of Nitrocefin, the product cephalosporanic acid is produced and turns the filter paper red. A negative result is indicated by a lack of color change on the filter paper. The test is simple, requires no additional reagents and will yield reliable results in 5 minutes or less!
M1251 | BugDisc™ Nitrocefin Disc DataSheet
Sort Name: Nitrocefin Disc
Label Name: Nitrocefin Discs
Taglines: Quick, easy testing of bacterial colonies for the detection of β-Lactamase
Product Highlights: • Easy, ready-to use discs • Results in less than 10 min • No special equipment, no calibrators needed
Packaging: EA
Additional Information
Storage Temperature: |
-20°C |
Shipping: |
Gel Pack |
Shelf Life: |
12 months |