Busulfan | B1063

Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. Busulfan causes DNA damage by cross-linking DNA and proteins. Causes double-base lesions mainly at 5'-GA-3' and, to a lesser extent, at 5'-GG-3' sequences. Forms an intrastrand cross-link at the 5'-GA-3' sequence, and to monoalkylation. Induces normal human fibroblast senescence selectively through Erk and p38 pathways.

Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. Busulfan causes DNA damage by cross-linking DNA and proteins. Causes double-base lesions mainly at 5'-GA-3' and, to a lesser extent, at 5'-GG-3' sequences. Forms an intrastrand cross-link at the 5'-GA-3' sequence, and to monoalkylation. Induces normal human fibroblast senescence selectively through Erk and p38 pathways.

B1063 | Busulfan DataSheet

Alternate Name/Synonyms: 1,4-Butanediol dimethanesulfonate

Appearance: White solid

Formulation: N/A

CAS Number: 55-98-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₆H₁₄O₆S₂

Molecular Weight: 246.3

Cell-Permeable?: Yes

Purity: ≥97%

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A bifunctional alkylating agent

MDL Number: MFCD00007562

PubChem CID: 2478

SMILES: CS(=O)(=O)OCCCCOS(=O)(=O)C

InChi: InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3

InChi Key: COVZYZSDYWQREU-UHFFFAOYSA-N