Description
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. Busulfan causes DNA damage by cross-linking DNA and proteins. Causes double-base lesions mainly at 5'-GA-3' and, to a lesser extent, at 5'-GG-3' sequences. Forms an intrastrand cross-link at the 5'-GA-3' sequence, and to monoalkylation. Induces normal human fibroblast senescence selectively through Erk and p38 pathways.
Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. Busulfan causes DNA damage by cross-linking DNA and proteins. Causes double-base lesions mainly at 5'-GA-3' and, to a lesser extent, at 5'-GG-3' sequences. Forms an intrastrand cross-link at the 5'-GA-3' sequence, and to monoalkylation. Induces normal human fibroblast senescence selectively through Erk and p38 pathways.
Alternate Name/Synonyms: 1,4-Butanediol dimethanesulfonate
Appearance: White solid
Formulation: N/A
CAS Number: 55-98-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₆H₁₄O₆S₂
Molecular Weight: 246.3
Cell-Permeable?: Yes
Purity: ≥97%
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A bifunctional alkylating agent
MDL Number: MFCD00007562
PubChem CID: 2478
SMILES: CS(=O)(=O)OCCCCOS(=O)(=O)C
InChi: InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3
InChi Key: COVZYZSDYWQREU-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |