Butyrolactone 3 | B2817

Butyrolactone 3 is an inhibitor of histone acetyltransferase (HAT) Gcn5. Gcn5 acetylates histones H2B and H3. Butyrolactone 3 inhibits Gcn5 with an IC₅₀ value of 100 μM. It has an affinity to the Gcn5 enzyme similar to its substrate, histone H3. It inhibits pre-mRNA splicing with an IC₅₀ of 0.5 mM.

Butyrolactone 3 is an inhibitor of histone acetyltransferase (HAT) Gcn5. Gcn5 acetylates histones H2B and H3. Butyrolactone 3 inhibits Gcn5 with an IC₅₀ value of 100 μM. It has an affinity to the Gcn5 enzyme similar to its substrate, histone H3. It inhibits pre-mRNA splicing with an IC₅₀ of 0.5 mM.

B2817 | Butyrolactone 3 DataSheet

Alternate Name/Synonyms: rel-tetrahydro-4-methylene-5-oxo-2R-propyl-3S-furancarboxylic acid

Appearance: Crystalline solid

Formulation:

CAS Number: 778649-18-6

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₉H₁₂O₄

Molecular Weight: 184.19

Cell-Permeable?: False

Purity: ≥95%

Solubilities: ~2 mg/ml in PBS, pH 7.2 in 0, ~14 mg/ml in ethanol and DMSO in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of histone acetyltransferase Gcn5

MDL Number:

PubChem CID: 10081070

SMILES: CCCC1C(C(=C)C(=O)O1)C(=O)O

InChi: InChI=1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m0/s1

InChi Key: SRQUTZJZABSZRQ-NKWVEPMBSA-N