C K-666 | B2147

CK-666 is a potent, selective and reversible inhibitor of ARP2/3 complex (actin related proteins 2 and 3) with an IC₅₀ = 4 µM for human ARP2/3. Blocks actin nucleation and radically alters lamellipodial actin architecture, suspended cell shape and the cell spreading process. CK-666 attenuates BBB dysfunction induced by methamphetamine. A key new tool for studying actin assembly and the diverse range of actin-related processes in normal and pathophysiology.

CK-666 is a potent, selective and reversible inhibitor of ARP2/3 complex (actin related proteins 2 and 3) with an IC₅₀ = 4 µM for human ARP2/3. Blocks actin nucleation and radically alters lamellipodial actin architecture, suspended cell shape and the cell spreading process. CK-666 attenuates BBB dysfunction induced by methamphetamine. A key new tool for studying actin assembly and the diverse range of actin-related processes in normal and pathophysiology.

B2147 | C K-666 DataSheet

Alternate Name/Synonyms: 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide

Appearance: Cream colored solid

Formulation: N/A

CAS Number: 442633-00-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₇FN₂O

Molecular Weight: 296.3

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (45 mg/ml) or EtOH (30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, selective and reversible inhibitor of ARP2/3 complex

MDL Number: MFCD03036271

PubChem CID: 589075

SMILES: CC1=C(C2=CC=CC=C2N1)CCNC(=O)C3=CC=CC=C3F

InChi: InChI=1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)

InChi Key: UXRKUKRXVWJFER-UHFFFAOYSA-N