C4orf31 Antibody (N-term) [APR11261G]

C4orf31 Antibody (N-term) [APR11261G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This C4orf31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-109 amino acids of human C4orf31.

Cellular Localisation: Secreted

Molecular Weight: 64673

Clone: Polyclonal

Gene Name: NDNF

Gene ID: 79625

Function: Secretory protein that plays a role in various cellular processes (PubMed:20969804, PubMed:24706764, PubMed:31883645) . Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus (PubMed:31883645) . Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system (PubMed:20969804, PubMed:31883645) . May also act through the regulation of growth factors activity and downstream signaling (PubMed:31883645) . Also regulates extracellular matrix assembly and cell adhesiveness (By similarity) . Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764) .

Summary: Tissue Location: Expressed in neurons along the gonadotropin- releasing hormone (GnRH) expressing neurons migratory route

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Protein NDNF, Neuron-derived neurotrophic factor, NDNF, C4orf31