C87 | B3062

C87 is an inhibitor of Tumor Necrosis Factor α (TNFα). It binds to human TNFα with a KD of 110 nM and potently inhibits TNFα-induced cytotoxicity in L929 cells with an IC₅₀ of 8.73 μM. It effectively blocks TNFα-triggered signaling pathways and attenuates TNFα-induced inflammation in a mouse model of hepatitis.

C87 is an inhibitor of Tumor Necrosis Factor α (TNFα). It binds to human TNFα with a KD of 110 nM and potently inhibits TNFα-induced cytotoxicity in L929 cells with an IC₅₀ of 8.73 μM. It effectively blocks TNFα-triggered signaling pathways and attenuates TNFα-induced inflammation in a mouse model of hepatitis.

B3062 | C87 DataSheet

Alternate Name/Synonyms: 4-[(4-chloro-3-nitrophenyl)diazenyl]-5-phenyl-2-(4-phenyl-1,3-thiazol-2-yl)-1H-pyrazol-3-one; 3-phenyl-1-(4-phenyl-1,3-thiazol-2-yl)-1H-pyrazole-4,5-dione 4-({4-chloro-3-nitrophenyl}hydrazone); 4-[(E)-2-(4-chloro-3-nitrophenyl)hydrazono]-5-phenyl-2-(4-phenyl-1,3-thiazol-2-yl)-2,4-dihydro-3H-pyrazol-3-one; TNF-TNFR Signaling Inhibitor IV

Appearance: Orange Red Solid

Formulation:

CAS Number: 332420-90-3

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₂₄H₁₅ClN₆O₃S

Molecular Weight: 502.93

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: 5 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of Tumor Necrosis Factor α

MDL Number: MFCD00810005

PubChem CID: 4016403

SMILES: C1=CC=C(C=C1)C2=CSC(=N2)N3C(=O)C(=C(N3)C4=CC=CC=C4)N=NC5=CC(=C(C=C5)Cl)[N+](=O)[O-]

InChi: InChI=1S/C24H15ClN6O3S/c25-18-12-11-17(13-20(18)31(33)34)27-28-22-21(16-9-5-2-6-10-16)29-30(23(22)32)24-26-19(14-35-24)15-7-3-1-4-8-15/h1-14,29H

InChi Key: HTEQQWJUYYUNQG-UHFFFAOYSA-N