CABC1 antibody (Ascites) [APG02322G]

CABC1 antibody (Ascites) [APG02322G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H

Specificity: This CABC1 monoclonal antibody is generated from mouse immunized with CABC1 recombinant protein.

Cellular Localisation: Mitochondrion. Membrane; Single-pass membrane protein {ECO:0000255, ECO:0000305|PubMed:25216398}

Molecular Weight: 71950

Clone: Monoclonal

Gene Name: COQ8A {ECO:0000303|PubMed:27499294, ECO:0000312|HGNC:HGNC:16812}

Gene ID: 56997

Function: Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25498144, PubMed:21296186, PubMed:25540914, PubMed:27499294) . Its substrate specificity is unclear: does not show any protein kinase activity (PubMed:25498144, PubMed:27499294) . Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (PubMed:25498144, PubMed:27499294) . Shows an unusual selectivity for binding ADP over ATP (PubMed:25498144) .

Summary: Tissue Location: Widely expressed, with highest levels in adrenal gland, heart, pancreas, nasal mucosa, stomach, uterus and skeletal muscle.

Form: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:500~16000

Synonyms: Chaperone activity of bc1 complex-like, mitochondrial, Chaperone-ABC1-like, 2711-, aarF domain-containing protein kinase 3, ADCK3, CABC1