Calphostin C | 2611

A potent and highly specific cell-permeable protein kinase C (PKC) inhibitor . The inhibition of PKC is light-dependent. Also inhibits PKA, PKG, DAG kinase, phospholipase D1 and D2, myosin light chain kinase and c-Src . Anticancer compound. Inhibits cell proliferation and strongly induces apoptosis in vitro. Shown to directly and potently block L-type calcium channels. Calphostin C specifically inhibits contraction-stimulated glucose transport but not insulin-stimulated glucose transport in skeletal muscle. Also Wnt/β-catenin/lef-1 signaling inhibitor.

Calphostin C is a potent and highly specific cell-permeable protein kinase C (PKC) inhibitor . The inhibition of PKC is light-dependent. Also inhibits PKA, PKG, DAG kinase, phospholipase D1 and D2, myosin light chain kinase and c-Src.

2611 | Calphostin C DataSheet

Alternate Name/Synonyms: (1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonic acid 4-hydroxyphenyl esterUCN 1028C; PKF115-584; Cal-C

Appearance: Dark red solid

Formulation: N/A

CAS Number: 121263-19-2

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₄₄H₃₈O₁₄

Molecular Weight: 790.76

Cell-Permeable?: Yes

Purity: >95% by HPLC

Solubilities: DMSO or EtOH

Handling: Protect from air and light

Country of Origin: USA

Tag Line: Apotent protein kinase C (PKC) inhibitor

MDL Number: MFCD00133155

PubChem CID: 2533

SMILES: CC(CC1=C(C(=C2C(=O)C=C(C3=C4C(=CC(=O)C5=C(C(=C(C(=C45)C1=C32)CC(C)OC(=O)OC6=CC=C(C=C6)O)OC)O)OC)OC)O)OC)OC(=O)C7=CC=CC=C7

InChi: InChI=1S/C44H38O14/c1-20(56-43(50)22-10-8-7-9-11-22)16-25-31-32-26(17-21(2)57-44(51)58-24-14-12-23(45)13-15-24)42(55-6)40(49)34-28(47)19-30(53-4)36(38(32)34)35-29(52-3)18-27(46)33(37(31)35)39(48)41(25)54-5/h7-15,18-21,45,48-49H,16-17H2,1-6H3

InChi Key: LSUTUUOITDQYNO-UHFFFAOYSA-N