Calumenin (C-terminus) monoclonal Antibody | MB0120

Calumenin (C-terminus) monoclonal Antibody | MB0120 | Gentaur UK, US & Europe Distribution

Host: Mouse IgG1

Reactivity: Human,Mouse

Application: WB

Application Range: WB:1:1000

Background: Caluminin is a 315 amino acid Ca2+-binding member of the CREC, EF-hand protein family. Calumenin is a secreted protein t hat contains six Ca2+-binding (EF-hand) motifs and is expressed in the lumen of the endoplasmic reticulum (ER) and Golgi apparatus. In the presence of Ca2+, Calumenin interacts with serum amyloid P component (SAP) and, together, they may play a role in the immunological defense system and participate in amyloidosis, the pathological formation of amyloid deposits in different types of tissues. Calumenin has an inhibitory effect on the vitamin K-dependent g-carboxylation system which converts vitamin K-dependent proteins to Gla-containing proteins. Calumenin may also be involved in the pathophysiology of thrombosis and/or wound healing by acting in an autocrine or paracrine manner.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Calumenin (C-terminus) mAb detects endogenous levels of Calumenin protein.

Molecular Weight: Predicted band size:37KDa Observed band size:45KDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Crocalbin; IEF SSP 9302; CALU

Immunogen: Synthetic peptide, corresponding to amino acids C-terminus of Human Calumenin.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: