CARD16 Polyclonal Antibody | E-AB-17810

CARD16 Polyclonal Antibody | E-AB-17810 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: CAR16, CARD only domain-containing protein 1, CARD only protein , CARD16, Caspase recruitment domain family, member 16, Caspase recruitment domain-containing protein 16, Caspase-1 dominant-negative inhibitor pseudo-ICE , Caspase-1 inhibitor COP, COP, COP1, Pseudo interleukin 1 beta converting enzyme, Pseudo interleukin-1 beta converting enzyme, Pseudo interleukin-1beta converting enzyme , PSEUDO-ICE

Application: WB, IHC, ELISA

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Cell Biology

Background: Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.

Concentration: 1.1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human CARD16

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 23 kDa

Molecular Weight(Observed): Refer to figures