Caspase-1 Assay Kit (Colorimetric) | KTA3020

Caspase-1 Assay Kit (Colorimetric) | KTA3020 | Gentaur UK, US & Europe Distribution

Product Category: Cytology

Application: Cellular states

Product Type: Apoptosis Detection Kit

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protein Lenght: N/A

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Kit Component: • Cell Lysis Buffer
• Reaction Buffer (2×)
• Ac-VDQQD-pNA (4mM)
• pNA (10mM)
• DTT (100×)

Features & Benefits : • Simple and optimized procedure.
• Fast and convenient.
• Detect early/middle stages of apoptosis.

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Storage Conditions: Stable for at least 12 months at recommended temperature from date of shipment. Gel pack with blue ice.

Shipping: Gel pack with blue ice.

Background: Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Mammalian caspases can be subdivided into three functional groups: initiator caspases (Caspase 2, 8, 9 and 10), executioner caspases (Caspase-3, 6 and 7), and inflammatory caspases (Caspase 1, 4, 5, 11 and 12) . Caspase 2 belongs to a family of cysteine proteases that cleave proteins only at an amino acid following an aspartic acid residue. Within this family, caspase 2 is part of the Ich-1 subfamily, one of the most conserved caspases in different species of animal. It has a similar amino acid sequence to initiator caspases, including caspase 1, caspase 4, caspase 5, and caspase 9. It is produced as a zymogen, which contains a long pro-domain that is similar to that of caspase 9 and contains a protein interaction domain known as a CARD domain. Pro-caspase-2 contains two subunits, p19 and p12.

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Tag: Caspase