Caspase-1 P10 Polyclonal Antibody | BS65859

Caspase-1 P10 Polyclonal Antibody | BS65859 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Mouse,Rat,

Application: WB,

Application Range: WB=1:500-2000

Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq].

Storage & Stability: Store at 4°C short term. Aliquot and store at -32°C long term. Avoid freeze-thaw cycles.

Specificity: Caspase-1 P10 Polyclonal Antibody detects endogenous levels of Caspase-1 P10 protein.

Molecular Weight: ~45/10 kDa kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: caspase-1 isoform alpha p10 subunit; CASP 1; CASP1; Caspase 1 apoptosis related cysteine peptidase; Caspase 1 apoptosis related cysteine protease; Caspase1; ICE; IL 1 beta converting enzyme; IL 1BC; IL1B convertase; IL1BC; IL1BCE; Interleukin 1 beta convertase; Interleukin 1 beta convertase precursor; Interleukin 1 beta converting enzyme. CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45; Caspase-1 subunit p10.

Immunogen: KLH conjugated synthetic peptide derived from mouse Caspase-1 P10:301-380/402

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: