Description
Caspase family of cysteine proteases plays a key role in apoptosis. Caspase-10 is expressed in many tissues and cell lines. Similar to other caspases, caspase-10 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Four isoforms of caspase-10 have been identified: caspase-10a (Mch4), caspase-10b (FLICE2), caspase-10c and caspase-10d. They have the same prodomain but different mature large and small subdomains. Activated caspase-10 activates caspase-3,-4,-6,-7,-8, and 9, which are then involved in proteolytic cleavage of many cellular proteins. Caspase-10 has been shown to be involved in the Fas and TNFR1 - induced apoptosis.
6677 | Caspase-10 Antibody DataSheet
Antibody Target: Caspase-10
Target Alternative Name: FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE2, ICE like Apoptotic Protease 4
Tag Line: Polyclonal Antibody to detect Caspase-10 in human samples
Category: Caspase-10
Host: Rabbit
Isotype: Rabbit IgG
Species Reactivities: Human
Immunogen Sequence: Human recombinant Caspase-10/a (Cat # 1090A)
Accession #: Q92851
Gene ID: 843
Appearance: Colorless liquid
Form: Liquid
Concentration: 0.5 mg/ml
Formulation: 100 µg (0.5 mg/ml) of Caspase-10 antibody in PBS pH 7.2, 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.
Purification: Affinity Purified Antibody
Application: Western blot
Positive Control: Western Blot: Recombinant protein
Application And Usages: Western blot: 1-4 µg
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: Verified
Immunocytochemistry Verified: Not Verified
Immunofluorescence Verified: Not Verified
Immunoprecipitation Verified: Not Verified
FACS Verified:
ELISA Verified: Not Verified
ChIP Verified: Not Verified
Dot Blot Verified: Not Verified
Flow Cytometry Verified: Not Verified
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
12 months |