Caspase-4 Assay Kit (Colorimetric) | KTA3023

Caspase-4 Assay Kit (Colorimetric) | KTA3023 | Gentaur UK, US & Europe Distribution

Product Category: Cytology

Application: Cellular states

Product Type: Apoptosis Detection Kit

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Kit Component: • Cell Lysis Buffer
• Reaction Buffer (2×)
• Ac-VEID-pNA (4mM)
• pNA (10mM)
• DTT (100×)

Features & Benefits : • Simple and optimized procedure.
• Fast and convenient.
• Detect early/middle stages of apoptosis.

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Storage Conditions: Stable for at least 12 months at recommended temperature from date of shipment. Gel pack with blue ice.

Shipping: Gel pack with blue ice.

Background: Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Mammalian caspases can be subdivided into three functional groups: initiator caspases (Caspase 2, 8, 9 and 10), executioner caspases (Caspase-3, 6 and 7), and inflammatory caspases (Caspase 1, 4, 5, 11 and 12) . Caspase-6 (also known as Mch2) is a member of the caspase-family of cysteine proteases. During apoptosis procaspase-6 is processed at aspartate residues by self-proteolysis and/or cleavage by another caspase. The processed active form of caspase-6 consists of large (18 kDa) and small (11 kDa) subunits which associate to form the active enzyme. Active caspase-6 has been shown involving in the proteolysis of PARP (poly ADP-ribose polymerase), an enzyme that is involved in DNA repair and genomic maintenance.

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Tag: Caspase