Caspase-8 Inhibitor Z-IETD-FMK | 1064

A synthetic peptide that irreversibly inhibits FLICE and related protease/caspase activity and blocks apoptosis. IETD is the specific recognition sequence found in CPP32 proenzyme. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups.)

Z-IETD-FMK is a cell-permeable, irreversible inhibitor of caspase-8/Granzyme B.

1064 | Caspase-8 Inhibitor Z-IETD-FMK DataSheet

Alternate Name/Synonyms: Z-IETD-FMK, Caspase-8 Inhibitor, Z-IETD-fluoromethylketone

Appearance: Liquid

Formulation: DMSO (2 mM)

CAS Number: N/A

Structure Available?: No

Peptide sequence: Z-Ile-Glu(OMe)-Thr-Asp(OMe)-FMK

Salt Form: No

Molecular Formula: C₃₀H₄₃FN₄O₁₁

Molecular Weight: 654.7

Cell-Permeable?: Yes

Purity: >99% by HPLC

Solubilities: N/A

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A Caspase-8 inhibitor

MDL Number: MFCD01861686

PubChem CID: 44135212

SMILES: CCC(C)C(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)O)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O) OCC1=CC=CC=C1

InChi: InChI=1S/C30H43FN4O11/c1-6-17(2)25(35-30(43)46-16-19-10-8-7-9-11-19)28 (41)32-20(12-13-23(38)44-4)27(40)34-26(18(3)36)29(42)33-21(22(37)15-31) 14-24(39)45-5/h7-11,17-18,20-21,25-26,36H,6,12-16H2,1-5H3,(H,32,41)(H, 33,42)(H,34,40)(H,35,43)

InChi Key: PHLCQASLWHYEMX-UHFFFAOYSA-N