Cathepsin H polyclonal Antibody | BS61768

Cathepsin H polyclonal Antibody | BS61768 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Cathepsin H (also designated N-benzoylarginine-β-naphthylamide hydrolase, aleurain, cathepsin B3 or cathepsin BA) is a lysosomal cysteine proteinase that mediates degradation of lysosomal proteins. Cathepsin H is a disulfidelinked heavy and light chain dimer produced from a single precursor protein. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Elevated levels of cathepsin H correlates with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene. Full-length and truncated cathepsin H [12 amino acid deletion in the signal peptide region (CTSH∆10-21) ] are expressed in prostate tissues, LNCaP, PC-3 and DU-145 prostate cancer cell lines. Cathepsin H mediates maturation of the biologically active surfactant protein-B (SP-B) peptide.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Cathepsin H polyclonal Antibody detects endogenous levels of Cathepsin H protein.

Molecular Weight: ~ 37 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Pro-cathepsin H; Cathepsin H mini chain; Cathepsin H; Cathepsin H heavy chain; Cathepsin H light chain; CTSH; CPSB

Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human Cathepsin H.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: