CAV3 Antibody (N-term) [APR05759G]

CAV3 Antibody (N-term) [APR05759G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CAV3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5-31 amino acids from the N-terminal region of human CAV3.

Cellular Localisation: Golgi apparatus membrane; Peripheral membrane protein. Cell membrane {ECO:0000250|UniProtKB:P51638}; Peripheral membrane protein. Membrane, caveola {ECO:0000250|UniProtKB:P51637}; Peripheral membrane protein. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P51637}. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity)

Molecular Weight: 17259

Clone: Polyclonal

Gene Name: CAV3

Gene ID: 859

Function: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity) . Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae (PubMed:19262564) .

Summary: Tissue Location: Expressed predominantly in muscle.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:500 WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Caveolin-3, M-caveolin, CAV3