CCDC141 Antibody | 6399

CCDC141 Antibody | 6399 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Homology: N/A

Immunogen: CCDC141 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CCDC141.
The immunogen is located within amino acids 40 - 90 of CCDC141.

Research Area: Homeostasis

Tested Application: E, WB, IHC-P, IF

Application: CCDC141 antibody can be used for detection of CCDC141 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Specificiy: At least four isoforms of CCDC141 are known to exist.

Positive Control 1: Cat. No. 1220 - SK-N-SH Cell Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: CCDC141 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: CCDC141 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: CCDC141 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: CCDC141 Antibody: CAMDI, Coiled-coil domain-containing protein 141

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: CCDC141 Antibody: Coiled-coil domain-containing protein 141 (CCDC141) , also known as CAMDI, is a recently identified disrupted in schizophrenia 1 (DISC1) -binding protein that also associates with myosin II. CCDC141 preferentially associates with phosphomyosin II and causes an accumulation of phosphomyosin II at the centrosome in a DISC1-dependent manner. Knockdown of CCDC141 expression by RNAi led to severely impaired radial migration with disoriented chromosomes, suggesting that CCDC141 is required for radial migration through DISC1 and myosin II-mediated centrosome positioning during neuronal development.