CCNC polyclonal Antibody | BS6824

CCNC polyclonal Antibody | BS6824 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100

Background: The proliferation of eukaryotic cells is controlled at specific points in the cell cycle, particularly at the G1 to S and the G2 to M transitions. It is well established that the Cdc2 p34-cyclin B protein kinase plays a critical role in the G2 to M transition while cyclin A associates with Cdk2 p33 and functions in S phase. Considerable effort directed towards the identi- fication of G1 cyclins has led to the isolation of cyclin D, cyclin C and cyclin E. Cyclin D corresponds to a putative human oncogene designated PRAD1 which maps at the site of the BCL1 rearrangement in certain lymphomas and leukemias. Cyclin C complexes with the cyclin dependent kinase Cdk8. The cyclin C/Cdk8 complex has been shown to have kinase activity toward the carboxy terminal domain of RNA polymerase II. Two complexes have been identified which contain cyclin C/Cdk8.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CCNC polyclonal Antibody detects endogenous levels of CCNC protein.

Molecular Weight: ~ 26-33 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Cyclin-C; SRB11 homolog; hSRB11; CCNC

Immunogen: Recombinant full length Human CCNC.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: