Description
CCNC polyclonal Antibody | BS6824 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC IF
Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100
Background: The proliferation of eukaryotic cells is controlled at specific points in the cell cycle, particularly at the G1 to S and the G2 to M transitions. It is well established that the Cdc2 p34-cyclin B protein kinase plays a critical role in the G2 to M transition while cyclin A associates with Cdk2 p33 and functions in S phase. Considerable effort directed towards the identi- fication of G1 cyclins has led to the isolation of cyclin D, cyclin C and cyclin E. Cyclin D corresponds to a putative human oncogene designated PRAD1 which maps at the site of the BCL1 rearrangement in certain lymphomas and leukemias. Cyclin C complexes with the cyclin dependent kinase Cdk8. The cyclin C/Cdk8 complex has been shown to have kinase activity toward the carboxy terminal domain of RNA polymerase II. Two complexes have been identified which contain cyclin C/Cdk8.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: CCNC polyclonal Antibody detects endogenous levels of CCNC protein.
Molecular Weight: ~ 26-33 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Cyclin-C; SRB11 homolog; hSRB11; CCNC
Immunogen: Recombinant full length Human CCNC.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: