LBD
CCND2 Antibody (C-term S279/T280) [APR04567G]
- SKU:
- LBD-APR04567G
- Availability:
- Usually ships in 5 working days
Description
CCND2 Antibody (C-term S279/T280) [APR04567G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This CCND2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-285 amino acids from the C-terminal region of human CCND2.
Cellular Localisation: Nucleus. Cytoplasm. Nucleus membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members
Molecular Weight: 33067
Clone: Polyclonal
Gene Name: CCND2 {ECO:0000303|PubMed:1386336, ECO:0000312|HGNC:HGNC:1583}
Gene ID: 894
Function: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G (1) /S transition (PubMed:8114739, PubMed:18827403) . Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G (1) phase (PubMed:8114739, PubMed:18827403) . Hypophosphorylates RB1 in early G (1) phase (PubMed:8114739, PubMed:18827403) . Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:8114739, PubMed:18827403) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: G1/S-specific cyclin-D2, CCND2