LBD
CCR4 Antibody (C-term) [APR04287G]
- SKU:
- LBD-APR04287G
- Availability:
- Usually ships in 5 working days
Description
CCR4 Antibody (C-term) [APR04287G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This CCR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-290 amino acids from the C-terminal region of human CCR4.
Cellular Localisation: Cell membrane; Multi-pass membrane protein.
Molecular Weight: 41403
Clone: Polyclonal
Gene Name: CCR4
Gene ID: 1233
Function: High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G (i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Summary: Tissue Location: Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA) . Expressed in brain microvascular and coronary artery endothelial cells.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: C-C chemokine receptor type 4, C-C CKR-4, CC-CKR-4, CCR-4, CCR4, K5-5, CD194, CCR4, CMKBR4