CCT-137690 | B1935

CCT137690 is a highly selective and orally bioavailable inhibitor of Aurora A, Aurora B and Aurora C with IC₅₀ of 15 nM, 25 nM and 19 nM, respectively. Displays anti-tumor activities both in vitro and in vivo. B

CCT137690 is a highly selective and orally bioavailable inhibitor of Aurora A, Aurora B and Aurora C with IC₅₀ of 15 nM, 25 nM and 19 nM, respectively. Displays anti-tumor activities both in vitro and in vivo. B

B1935 | CCT-137690 DataSheet

Alternate Name/Synonyms: 3-[[4-[6-bromo-2-[4-(4-methylpiperazin-1-yl)phenyl]-1H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]methyl]-5-methyl-1,2-oxazole

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1095382-05-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₃₁BrN₈O

Molecular Weight: 551.48

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 7 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent Aurora kinases inhibitor

MDL Number: N/A

PubChem CID: 25154041

SMILES: CC1=CC(=NO1)CN2CCN(CC2)C3=C4C(=NC=C3Br)N=C(N4)C5=CC=C(C=C5)N6CCN(CC6)C

InChi: InChI=1S/C26H31BrN8O/c1-18-15-20(31-36-18)17-33-9-13-35(14-10-33)24-22(27)16-28-26-23(24)29-25(30-26)19-3-5-21(6-4-19)34-11-7-32(2)8-12-34/h3-6,15-16H,7-14,17H2,1-2H3,(H,28,29,30)

InChi Key: GFLQCBTXTRCREJ-UHFFFAOYSA-N