CD105 Antibody [MJ7/18] | 99-004

CD105 Antibody [MJ7/18] | 99-004 | Gentaur UK, US & Europe Distribution

Host: Rat

Reactivity: Mouse

Homology: N/A

Immunogen: Inflamed mouse skin

Research Area: Stem Cell

Tested Application: IHC-Fr, Flow

Application: CD105 Antibody [MJ7/18] for use in flow cytometry, immunohistochemistry, western blotting, immunoprecipitation, and separation assays.

Specificiy: CD105

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [MJ7/18]

Isotype: IgG2a

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

Concentration: 0.5 mg/mL

Storage Condition: Store vial at 2-8˚C

Alternate Name: Endoglin

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: CD105, also known as endoglin, is a disulfide-linked type II transmembrane homodimer that is predominantly expressed on vascular endothelial cells. It is also found on pre-erythroblasts, macrophages, and lymphoid and myeloid leukemic cells. Both mouse and human CD105 exhibit >70% sequence homology in their cytoplasmic domains with type III transforming growth factor beta (TGFbeta) receptor. CD105 has been shown to be one of several receptors for the various isoforms of TGFbeta which in turn is one of a family of proteins involved in regulation of cell differentiation, migration of cells, and control of the immune response.