Description
CD105 Antibody [MJ7/18] | 99-004 | Gentaur UK, US & Europe Distribution
Host: Rat
Reactivity: Mouse
Homology: N/A
Immunogen: Inflamed mouse skin
Research Area: Stem Cell
Tested Application: IHC-Fr, Flow
Application: CD105 Antibody [MJ7/18] for use in flow cytometry, immunohistochemistry, western blotting, immunoprecipitation, and separation assays.
Specificiy: CD105
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [MJ7/18]
Isotype: IgG2a
Conjugate: Unconjugated
Physical State: Liquid
Buffer: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration: 0.5 mg/mL
Storage Condition: Store vial at 2-8˚C
Alternate Name: Endoglin
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: CD105, also known as endoglin, is a disulfide-linked type II transmembrane homodimer that is predominantly expressed on vascular endothelial cells. It is also found on pre-erythroblasts, macrophages, and lymphoid and myeloid leukemic cells. Both mouse and human CD105 exhibit >70% sequence homology in their cytoplasmic domains with type III transforming growth factor beta (TGFbeta) receptor. CD105 has been shown to be one of several receptors for the various isoforms of TGFbeta which in turn is one of a family of proteins involved in regulation of cell differentiation, migration of cells, and control of the immune response.