CD116 polyclonal Antibody | BS62545

CD116 polyclonal Antibody | BS62545 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Rat

Application: WB

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: The human IL-3, IL-5 and GM-CSF receptors are each composed of both unique a subunits and a common β subunit. The a subunits are low affinity ligand binding proteins while the β subunits do not themselves bind ligand, but are required for high affinity binding by the a subunits. In contrast, the mouse IL-3 receptor has two distinct β subunits, one that functions only in IL-3 mediated cell signaling and a second that is shared with IL-5 and GM-CSF. The murine β-subunits are 91% homologous at the amino acid level but only 56% homologous to the human β subunit. Although neither the murine nor the human β subunit contains tyrosine kinase domains, both activate tyrosine phosphorylation mediated signaling pathways.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CD116 polyclonal Antibody detects endogenous levels of CD116 protein.

Molecular Weight: ~ 46 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CD116; CD116 antigen; CDw116; Colony stimulating factor 2 receptor alpha chain; CSF 2R; CSF2R; CSF2RA; CSF2RAX; CSF2RAY; CSF2RX; CSF2RY; GM CSF R alpha; GM CSF receptor alpha subunit; GM-CSF-R-alpha; GMCSFR; GMCSFR-alpha; GMR-alpha; Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Immunogen: Synthetic peptide, corresponding to Human CD116.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: