CD117 Antibody| F40159-0.4ML

CD117 Antibody| F40159-0.4ML | Gentaur UK, US & Europe Distribution

Background: CD117 is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this receptor may be associated with some types of cancer. It is a receptor tyrosine kinase type III, which binds to stem cell factor (a substance that causes certain types of cells to grow), also known as steel factor or c-kit ligand. When this receptor binds to stem cell factor (SCF) it forms a dimer that activates its intrinsic tyrosine kinase activity, that in turn phosphorylates and activates signal transduction molecules that propagate the signal in the cell. Signalling through CD117 plays a role in cell survival, proliferation, and differentiation. [Wiki]

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human, Mouse

Predicted Spacies Reactivity: Pig

Application: WB, FACS, ELISA

Application Details: Western blot: 1:1000, Flow Cytometry: 1:10-1:50

Application Note: Titration of the CD117 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This CD117 antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 680-711 from the human protein was used as the immunogen for this CD117 antibody.

Storage: Aliquot the CD117 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A