CD11a Antibody [I21/7] (Biotin) | 98-628

CD11a Antibody [I21/7] (Biotin) | 98-628 | Gentaur UK, US & Europe Distribution

Host: Rat

Reactivity: Mouse, Human

Homology: N/A

Immunogen: Whole BW5147 cells

Research Area: Cancer

Tested Application: E, IHC-Fr, ICC, Neut

Application: CD11a Antibody [I21/7] for use in flow cytometry, immunohistochemistry / immunocytochemistry, and immunoprecipitation assays.

Specificiy: CD11a

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [I21/7]

Isotype: IgG2a

Conjugate: Biotin

Physical State: Liquid

Buffer: Supplied in PBS/NaN3

Concentration: 0.5 mg/mL

Storage Condition: Store vial at 2-8˚C

Alternate Name: LFA-1, LFA-1alpha, integrin alphaL

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The monoclonal antibody I21/7 reacts with the alpha subunit of mouse and human CD11a, also known as LFA-1, and a member of the integrin family of cell adhesion molecules. The antigen is expressed on thymocytes, T and B lymphocytes, and on non-lymphoid cells in the bone marrow. CD11a appears to be an essential component for T-cell activation by antigen-presenting cells and is important for cell-mediated killing. Costimulatory signaling by LFA-1 is achieved by pairing with its ligand, CD54/ICAM-1.