Description
CD11a Antibody [I21/7] (Biotin) | 98-628 | Gentaur UK, US & Europe Distribution
Host: Rat
Reactivity: Mouse, Human
Homology: N/A
Immunogen: Whole BW5147 cells
Research Area: Cancer
Tested Application: E, IHC-Fr, ICC, Neut
Application: CD11a Antibody [I21/7] for use in flow cytometry, immunohistochemistry / immunocytochemistry, and immunoprecipitation assays.
Specificiy: CD11a
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [I21/7]
Isotype: IgG2a
Conjugate: Biotin
Physical State: Liquid
Buffer: Supplied in PBS/NaN3
Concentration: 0.5 mg/mL
Storage Condition: Store vial at 2-8˚C
Alternate Name: LFA-1, LFA-1alpha, integrin alphaL
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: The monoclonal antibody I21/7 reacts with the alpha subunit of mouse and human CD11a, also known as LFA-1, and a member of the integrin family of cell adhesion molecules. The antigen is expressed on thymocytes, T and B lymphocytes, and on non-lymphoid cells in the bone marrow. CD11a appears to be an essential component for T-cell activation by antigen-presenting cells and is important for cell-mediated killing. Costimulatory signaling by LFA-1 is achieved by pairing with its ligand, CD54/ICAM-1.